Myelodysplastic syndrome coexisting with acute lymphoblastic leukaemia.

t ( 2 ; 3 ) ( p 15 - 23 ; q 26 - 27 )

Clinics and pathology Disease Myeloid malignancies: myelodysplastic syndrome (MDS) in 1/4 of cases, with various FAB diagnoses (refractory anaemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)), acute non lymphocytic leukaemia (ANLL) in 60% of cases (M2-ANLL in 1/4 of all cases), blast crisi...

Eosinophilic myelodysplasia transforming to acute lymphoblastic leukaemia.

A 43 year old male presented with a marked eosinophilia and associated systemic symptoms. A diagnosis of myelodysplasia was made on the basis of bone marrow morphology and karyotype. Over a 12 month period the disease transformed into acute lymphoblastic leukaemia, confirmed by flow cytometry, cytochemistry, and immunohistochemistry. Karyotyping was abnormal with 5q- and -7 which persisted from...

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

Hereditary duplication of proximal chromosome 1q (q11q22) in a patient with T lymphoblastic lymphoma/leukaemia: a family study using G banding and comparative genomic hybridisation.

Aberrations of the long arm of chromosome 1 have been linked to many diseases, both in acquired somatic neoplastic conditions and constitutional genetic disorders. These abnormalities include structural rearrangements and various deletions or amplifications affecting whole chromosome arms or specific regions. Gain of chromosome 1q has been reported in many solid tumours, including invasive carc...

Current concerns in haematology. 2: Classification of acute leukaemia.

Introduction For the past century the classification of leukaemia has been predominantly clinical and morphological, supplemented in recent decades by the application of cytochemical techniques. During the past five to 10 years major advances in our knowledge of the nature of leukaemia consequent on the application of the techniques of immunology, cytogenetics, and molecular genetics, have take...